DTNA _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016456
Fusion event
HBV-DTNA integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1716
End
1751
Orient
-
Integrated sequence
CTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGA
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
32271972/34692008 (Hg38)
End
32272007/34692043 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA18A
Target gene
DTNA
miRNAs that regulate target gene
hsa-mir-8485
Nearest miRNA
hsa-mir-1-2/Upstream/4393048; hsa-mir-122/Downstream/899694;
Nearest TSS
ENST00000575820/Upstream/12471; ENST00000588949/Downstream/17313;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/197601, chr18-CpG: 19/Downstream/284647
Upstream sequence
GCATTTGGAGGCTCTTCACGGACAACACATGCCTACTTCACTGACTATAAATTGAAGCTAATTAACTTAGAATTATCGGAGCTTAACCCGAAATCTGAGA
Downstream sequence
TGTTATTTCTCTTTTTCTTCTGAATTTTTCATCAGAGACAAATGCCAAGTCTCCTCCTCTTTGAAGTTCCTATACCAAGTTCAGAAGTAGTCTTCCTTTC
Target sequence
CATTATCAATCACAGCACCATATCTTAGCTTCTCA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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