Basic Information
VIS ID
TVIS10016460
Fusion event
HBV-chr19 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
968
End
1003
Orient
-
Integrated sequence
AGGCCTATTGATTGGAAAGTATGTCAACGAATTGTG
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
6924732/6924721 (Hg38)
End
6924767/6924756 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ADGRE1 ; LOC105372256
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1227/Upstream/187943; hsa-let-7e/Downstream/692683;
Nearest TSS
ENST00000633603/Upstream/28315; ENST00000593558/Downstream/28455;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/156572, chr19-CpG: 25/Downstream/149985
Upstream sequence
TGGTCACCACTCCTGTTAAGGCCGAGGTGTCCCCTCACGGGGCTCCAGCTCTGAGCAACGGGCCACAGACACAGGCTCAGCTACTGCAGCCCCTGCAGGC
Downstream sequence
TTCTGCTGTGTCGCTCCATCCGAAATCACAACACCTACCTCCACCTGCACCTCTGCGTGTGTCTCCTCTTGGCGAAGACTCTCTTCCTCGCCGGTATACA
Target sequence
CTCCTTGGTGTGCCTCGTCTTGGCCATCGCCACCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate