FBL _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016461
Fusion event
HBV-FBL integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
791
End
826
Orient
-
Integrated sequence
TTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGT
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
40330907/39840267 (Hg38)
End
40330942/39840302 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
FBL
miRNAs that regulate target gene
hsa-mir-324-5p ; hsa-mir-181b-5p ; hsa-mir-20a-5p
Nearest miRNA
hsa-mir-10395/Upstream/10465; hsa-let-7e/Downstream/442241;
Nearest TSS
ENST00000633603/Upstream/2176; ENST00000596386/Downstream/139;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/5902, chr19-CpG: 42/Downstream/5935
Upstream sequence
CAACTCCACATTTTCTCTGTGGTAATACCCAACCCTTCCTCCTTCAACGGGGACTCACGAAGTGAACCTTTTCCTTTAGTTCTAAATTCCTGACCACACC
Downstream sequence
TCCTTTCCTCGACAAATGAAGACACCTGGGTGAGGGGATCAGAGCAGGGGTGAGGACCCCCAGCCTCTCCCTGCCCCGAAGCTCAGCCGGCTCCCTGCCT
Target sequence
CCCCAGGGACCAGGTTCTTGGTGACCAGTGCATCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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