Fusion event
HBV-C2orf91 integration
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
CTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCA
End
42179243/41952103 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-1301/Upstream/6480582; hsa-mir-10b/Downstream/5425572;
Upstream sequence
caaagcacctccctcccacgtaccagcctggcagctgatgtgatcagacctctgcctcagcaaaatctcaaattattacaggtcaggagccttctgcaaa
Downstream sequence
ACATAAAGTGGACTGTGTACATGCACTCTTTAGGAGCAGTCTTTTGGCCCCAAACTAGATTCTATGGGAATTCCCAGGTAAGATGCTTCTCCAAAATGAA
Target sequence
ggaagcCATTTTGATTATGATTATCAAAGTCTAGA
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.