Basic Information
VIS ID
TVIS10016467
Fusion event
HBV-chr2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
979
End
1014
Orient
+
Integrated sequence
TTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGG
Host Sequence
Chromosome
chr2
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
105839288/105222831 (Hg38)
End
105839323/105222866 (Hg38)
Orient
-
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/2790465; hsa-mir-10b/Downstream/3918624;
Nearest TSS
ENST00000437798/Upstream/78689; ENST00000258456/Downstream/18877;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/78271, chr2-CpG: 16/Downstream/13808
Nearby gene
MRPS9(-122870) ; GPR45(+18911) ;
Upstream sequence
ATAGCAGCTTATTTTTCTATTACCTGGGATGATGGTATCAGAGATAGGGACACTTTCCTTGTCATCCTTGACAGTGTAAACACTGACATTGTACTCCAGG
Downstream sequence
CTTCATTCAGATTTACCATCATGTGTCCTCCCTCCTCTTATGCTTCCCTTCCCCCTCCCAGCCCTCTGCTACCAGAATATAAATATGTGCTAAGAGAAAA
Target sequence
GGCTCTCAGCAAACCGTGGCTAATACCATCATCAG
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate