Basic Information
VIS ID
TVIS10016470
Fusion event
HBV-chr2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
683
End
718
Orient
-
Integrated sequence
AGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCC
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
112468498/111710921 (Hg38)
End
112468533/111710956 (Hg38)
Orient
+
Fragile sites / regions
FRA2S ; FRA2B
Nearest miRNA
hsa-mir-1285-2/Upstream/389835; hsa-mir-10b/Downstream/60105;
Nearest TSS
ENST00000437798/Upstream/103080; ENST00000473065/Downstream/69797;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/486163, chr2-CpG: 63/Downstream/172804
Upstream sequence
GTTGAGATGATACCAAAAAAAGGAGATAGTACAATGTCTACACTTTTAAAATTAGTTTCAAATAAAGTCTAAATGAATAATTTCCAATAGTAGTGTCCTT
Downstream sequence
TTCAGTTGCAAGTTTACAGCGAGGTTTGGTTTTGAACTGAAGCTCTTCTGGATGCCATGTTTTGGAAGCTGGTGGTAGGGCCGAGCTCTGCGACTCTGCT
Target sequence
CCTGTGTTTCTCACCCACAGGGAACTTGCAACAAT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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