Basic Information
VIS ID
TVIS10016473
Fusion event
HBV-chr2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1249
End
1284
Orient
-
Integrated sequence
TTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCT
Host Sequence
Chromosome
chr2
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
139936613/139179043 (Hg38)
End
139936648/139179078 (Hg38)
Orient
+
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-128-1/Upstream/3513565; hsa-mir-10b/Downstream/1407548;
Nearest TSS
ENST00000437798/Upstream/398695; ENST00000429008/Downstream/187087;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/397963, chr2-CpG: 58/Downstream/2951077
Nearby gene
YY1P2(-279904) ; LRP1B(+1052347) ;
Nearest cancer related gene
LRP1B(TSG, +1052347) ;
Upstream sequence
ctcatgatctgcctgcctcggcctcccaagtgctgggattacaggtgtgagccaccgcacctggccAGCCTTTGTATATTTTTATCACTTATATTTGAAT
Downstream sequence
CTTGAGATACAATAAAACTTGAAACGAGAATGCAGTCAATTAAGCTGCCTGAAAATGAGATGATGACTATCGTAGAAATATATTGGAAAAGATAGAAGGG
Target sequence
TTTCGAAGAGTTGTATGCAATAGTTTTACTGTTCA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate