Basic Information
VIS ID
TVIS10016475
Fusion event
HBV-chr2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
375
End
410
Orient
+
Integrated sequence
TGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTC
Host Sequence
Chromosome
chr2
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
149378986/148621417 (Hg38)
End
149379021/148621452 (Hg38)
Orient
-
Fragile sites / regions
FRA2S ; FRA2K
Nearest miRNA
hsa-mir-128-1/Upstream/8034732; hsa-mir-10b/Downstream/708826;
Nearest TSS
ENST00000437798/Upstream/109183; ENST00000449013/Downstream/22988;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/600456, chr2-CpG: 193/Downstream/22650
Upstream sequence
AAGCATCCCCTCCAAGGTGGTCTGCTGACAGTCTCTTCTGCTGTCTGCTGACTGGACTCTGGGATGCTTGTgaggcagttgtggggtggagcaagtaaca
Downstream sequence
CATTGCAAATTGGACCTCAAAAGACTTTTATCTATAAATAAGTAAAACCTACCCTCAGAGGAAAAGAAGTTTGCCTTCTCAGCAATAAGCAAACAGTAAA
Target sequence
CTGACGTTAGATTACCTGATTGTGACAAACTTGCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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