Basic Information
VIS ID
TVIS10016482
Fusion event
HBV-chr20 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2756
End
2791
Orient
-
Integrated sequence
CTCTATGGAAGGCGGGTATATTATATAAGAGAGAAA
Host Sequence
Chromosome
chr20
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
20999127/21018486 (Hg38)
End
20999162/21018521 (Hg38)
Orient
+
Fragile sites / regions
FRA20A
Nearest miRNA
hsa-mir-103a-2/Upstream/2547795; hsa-mir-1-1/Downstream/5189665;
Nearest TSS
ENST00000382410/Upstream/48038; ENST00000637005/Downstream/71175;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/305343, chr20-CpG: 38/Downstream/1603
Nearby gene
RALGAPA2(-305896) ; KIZ(+107461) ;
Upstream sequence
atgctaatgttctgacatgaatcagagagagtggaaacaacaggtgatctctgtaaatcttaatcagctctcatgtcttagatgtccactccaggaaaac
Downstream sequence
GCGCTCACAGTATAGAGACCAAGGACGGTGGACTCTCTTTCATAATGGCAGTGTAAACCACTTTGCATTAAGTAGGAATAATAACCTTTTTTTAAAGAAT
Target sequence
TGACTGCCGATTGTGTCTGGCATTGAATCTTCGGC
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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