Basic Information
VIS ID
TVIS10016485
Fusion event
HBV-EFCAB8 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1076
End
1111
Orient
+
Integrated sequence
CAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTAC
Host Sequence
Chromosome
chr20
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
31443039/32855233 (Hg38)
End
31443074/32855268 (Hg38)
Orient
+
Location type
Intronic
Target gene
EFCAB8
Nearest miRNA
hsa-mir-103a-2/Upstream/617386; hsa-mir-1-1/Downstream/1193851;
Nearest TSS
ENST00000382410/Upstream/976; ENST00000569087/Downstream/1353;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/34915, chr20-CpG: 30/Downstream/546070
Upstream sequence
AAAATGTAGGGCATACAGAATGCTGGAAGGAGGAGGGAACCTCCACACTTCTCAGAGCCCTGAGATGATCGTTCCCCGCAGTTTGTCATCAAACTATTAG
Downstream sequence
AATGCCACGGACCAGGAGTTAAGACCAGAGTCCTCTGCTAGGCCCTGCATCTGAAGTCTGCAGAGCATGGCTTTTCATTGGCTCAGTGAGGAGTTGAGTC
Target sequence
ACTGAAATAAATGAGGAAGACGGTGCTGTAAGTGG
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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