Basic Information
VIS ID
TVIS10016490
Fusion event
HBV-chr21 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
609
End
644
Orient
-
Integrated sequence
ATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGG
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
33525016/32152704 (Hg38)
End
33525051/32152739 (Hg38)
Orient
-
Nearest miRNA
hsa-let-7c/Upstream/1777326; hsa-mir-3197/Downstream/1397923;
Nearest TSS
ENST00000624081/Upstream/66409; ENST00000453549/Downstream/45074;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/278408, chr21-CpG: 63/Downstream/125858
Nearby gene
MIS18A(+1978) ;
Upstream sequence
ccacccttagccaggcaactggacaagtaaaattaaccatgacTAgtagtgaattgcacacttgtgctggaagtttccatccatcaagaggtacatcatt
Downstream sequence
ggccacacctaacttcaaaaatggcagggaaatgcgatcctattgagcctaaaaggaacttgaaccagaatatttgtgaacaTGTGAAGGTGACCACCAT
Target sequence
tctgcttaagccttattagccaaagcagatccgat
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate