Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016491
Fusion event
HBV-ACVR2B integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1399
End
1434
Orient
-
Integrated sequence
CTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCC
Host Sequence
Chromosome
chr3
Cytoband
p22.2
Reference genome
Start
End
38509429/38467938 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-215-5p ; hsa-mir-194-5p ; hsa-mir-141-3p ; hsa-mir-200c-3p ; hsa-mir-335-5p ; hsa-mir-140-3p ; hsa-mir-103a-3p ; hsa-mir-101-3p ; hsa-mir-221-3p ; hsa-mir-107 ; hsa-mir-4310 ; hsa-mir-4326 ; hsa-mir-3927-3p ; hsa-mir-4451 ; hsa-mir-6831-5p ; hsa-mir-7157-5p ; hsa-mir-29b-1-5p ; hsa-mir-134-3p ; hsa-mir-1304-5p ; hsa-mir-7114-5p ; hsa-mir-7854-3p ; hsa-mir-374a-5p ; hsa-mir-374b-5p ; hsa-mir-196a-5p ; hsa-mir-196b-5p ; hsa-mir-4761-5p ; hsa-mir-4464 ; hsa-mir-4748 ; hsa-mir-6867-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-4666a-3p ; hsa-mir-577 ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-203a-3p ; hsa-mir-5087 ; hsa-mir-6134 ; hsa-mir-576-5p ; hsa-mir-4263 ; hsa-mir-4799-5p ; hsa-mir-545-5p ; hsa-mir-4282 ; hsa-mir-6516-5p ; hsa-mir-3685 ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-7156-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-329-5p ; hsa-mir-384 ; hsa-mir-5692b ; hsa-mir-5692c ; hsa-mir-944 ; hsa-mir-369-3p ; hsa-mir-5571-5p ; hsa-mir-574-5p ; hsa-mir-2054 ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-6749-3p ; hsa-mir-126-3p ; hsa-mir-361-3p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-190a-3p ; hsa-mir-23b-3p ; hsa-mir-297 ; hsa-mir-511-3p ; hsa-mir-567 ; hsa-mir-6509-5p ; hsa-mir-6800-5p ; hsa-mir-6802-5p
Nearest miRNA
hsa-mir-12127/Upstream/498423; hsa-let-7g/Downstream/670268;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/12243, chr3-CpG: 39/Downstream/28253
Nearby gene
ACVR2B-AS1(-13118) ; EXOG(+28333) ;
Upstream sequence
GCTGTGCTCACAGGCCCTCTGAGCACACCCAGACTCCATTTCCCTCTTTCTCTCACTACCCTTAACATGTTTACACACGCCCCATGCCCAAATAATCTGG
Downstream sequence
gcaatctcagctcactgcaaccactgcccctctaggcttaagtgatcttcccacctcagcctttgaagtagctaggaccacaggtgcaaaccaccacaac
Target sequence
gtcttgctctgtcacccagggtggagtgcagcggt
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.