Basic Information
VIS ID
TVIS10016495
Fusion event
HBV-chr4 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
293
End
328
Orient
-
Integrated sequence
CGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTC
Host Sequence
Chromosome
chr4
Cytoband
p15.32
Reference genome
GRCh37/hg19
Start
17250494/17248871 (Hg38)
End
17250529/17248906 (Hg38)
Orient
-
Fragile sites / regions
FRA4D
Nearest miRNA
hsa-mir-12113/Upstream/3620914; hsa-mir-12115/Downstream/3279369;
Nearest TSS
ENST00000502981/Upstream/62812; ENST00000511148/Downstream/243602;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/887728, chr4-CpG: 79/Downstream/262780
Upstream sequence
AGTCATTAAGCAAAGAATTTGCACTCACTTCGCAGTAAGACTCCAAGCTGACCTTCTTTTAATAGTCTTATTTCTGAAAAGTTGTCAGGCACATCTCTTA
Downstream sequence
ctgtaccaaagctgttaaggagactaggaaagggacttctgatttctaccttaggagtagtgaactctagagtggaattttccaaatgggtgttcaaagg
Target sequence
gagagtcaggctatcaacagatcttgctcacatac
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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