Basic Information
VIS ID
TVIS10016497
Fusion event
HBV-chr4 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2983
End
3018
Orient
-
Integrated sequence
CAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCAC
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
21658722/21657099 (Hg38)
End
21658757/21657134 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
KCNIP4 ; LOC112268323
Nearest miRNA
hsa-mir-12113/Upstream/192341; hsa-mir-12115/Downstream/858178;
Nearest TSS
ENST00000502981/Upstream/75003; ENST00000511835/Downstream/40316;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/956386, chr4-CpG: 95/Downstream/291328
Upstream sequence
gcacacaaagtacacacacacacaaaacctcaaagtatgtgaatcaaaaacaacagaacaaaagcaggaaattgacaatccaaaattatagctggtgaat
Downstream sequence
GAGTAGTCATGTGGCAATAAGAGAAAGCACTATTGAGACTTTTCAACGCTGCTCTGTGATCACTTGCTTTTTAATTCTTTTATCAGTCTTTTTTTACTTG
Target sequence
AACAGTAATAATAGCTGAGAAATATTAACCACCCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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