Basic Information
VIS ID
TVIS10016503
Fusion event
HBV-chr6 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2433
End
2468
Orient
+
Integrated sequence
TCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCA
Host Sequence
Chromosome
chr6
Cytoband
q15
Reference genome
GRCh37/hg19
Start
88930246/88220527 (Hg38)
End
88930281/88220562 (Hg38)
Orient
-
Fragile sites / regions
FRA6G
Nearest miRNA
hsa-mir-10398/Upstream/9681218; hsa-mir-1202/Downstream/2092180;
Nearest TSS
ENST00000381078/Upstream/54168; ENST00000354922/Downstream/200471;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/52797, chr6-CpG: 60/Downstream/742603
Upstream sequence
gtctcatgcctccctaaaacgtatgaaaccaagcttcaccctgacaaccttggacacatgctctcagtacttcctgagggctgtatcatggaccatggtc
Downstream sequence
CAATGAGAAGCAGCATGAGGATCTCTAGAGTTAGACTCTATTACTAATCTTTGTGTCTCTGCAGAATACACAAATTGAGAATAGGTGGTAATTTGATCAT
Target sequence
TGTGTCTTTGTTTTGAAAGACTGGCGTTAAAGCTT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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