Basic Information
VIS ID
TVIS10016509
Fusion event
HBV-chr7 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1787
End
1822
Orient
+
Integrated sequence
GGCATAAATTGGTCTGCGCACCAGCACCATGCAACT
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
66144704/66679717 (Hg38)
End
66144739/66679752 (Hg38)
Orient
+
Fragile sites / regions
FRA7J
Nearest miRNA
hsa-mir-1183/Upstream/2000541; hsa-mir-10399/Downstream/434570;
Nearest TSS
ENST00000635602/Upstream/40861; ENST00000442563/Downstream/2412;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/24300, chr7-CpG: 135/Downstream/1986
Nearby gene
RABGEF1(+2374) ;
Upstream sequence
CCCTTGCACCGTTTGCCTGCCGTATCCGCCCAGGAGGGGGACAGGTACACAAGCAGGGCAAACTGTTTATTCatgaatgaatgaatgagtgagtgaatga
Downstream sequence
ggggcctaaactcatgcctgtaatcccagcactttgggaggccagggttggcagattgcttgagtccaggacttcgagaccagccagggcgacatggcaa
Target sequence
tctgctcagcttattgaacgctcattgtggggcca
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate