Basic Information
VIS ID
TVIS10016511
Fusion event
HBV-chr7 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
864
End
899
Orient
-
Integrated sequence
ACTCTCTAAATTTTATGGGTTATGTCATTGGATGTT
Host Sequence
Chromosome
chr7
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
94227397/94598085 (Hg38)
End
94227432/94598120 (Hg38)
Orient
-
Location type
Intronic
Target gene
CASD1 ; SGCE
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-140-5p ; hsa-mir-452-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-4789-3p ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-587 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-5580-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p
Nearest miRNA
hsa-mir-10525/Upstream/881080; hsa-mir-10399/Downstream/1621542;
Nearest TSS
ENST00000635602/Upstream/8064; ENST00000613043/Downstream/1017;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/87448, chr7-CpG: 112/Downstream/57426
Upstream sequence
TTCCTGCAGGGGAGGGGAGTTaaatggatcaaaaacagattataaactttgaaaactacaagaataaaactcttagaagaaaacatcagagaaaactttt
Downstream sequence
GCATAATGCTGCATTACAGCATTATATAGCATGGTCTCCCAAATGCAACTGTACAGTTTCCTCACCCCTCACCCTTGTCTACTCCTTACAAAGTCCTTCT
Target sequence
CACTAGGCTACATTATATCAGCAATATATGATGTA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate