Basic Information
VIS ID
TVIS10016514
Fusion event
HBV-chr7 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
3077
End
3112
Orient
+
Integrated sequence
TTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGC
Host Sequence
Chromosome
chr7
Cytoband
q35
Reference genome
GRCh37/hg19
Start
145730834/146033741 (Hg38)
End
145730869/146033776 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-10399/Upstream/2650941; hsa-mir-153-2/Downstream/1344241;
Nearest TSS
ENST00000635602/Upstream/352372; ENST00000637105/Downstream/82226;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1197581, chr7-CpG: 70/Downstream/82406
Nearby gene
TPK1(-1197688) ; CNTNAP2(+82618) ;
Nearest cancer related gene
CNTNAP2(TSG, +82618) ;
Upstream sequence
AATTCAGGGCAGAGAAACACTATAAAAGCCAGAAAAACTTTGAAACTATCCCTTACATCATGTTATAAGGACTAGAGTTGGTACACATTACTGAGAAAGC
Downstream sequence
AATAATGTATACCCACCTTATTATTTGAACTAAATTTTCTTATATGCTATAATTTAAAATATAACTTCAAAAATTTCAAATTTTTTCTTAAGGTTTCAGA
Target sequence
AATGCATGATCCCAACACATCCACAAAGTATGTAA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate