Basic Information
VIS ID
TVIS10016515
Fusion event
HBV-chr7 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
142
End
177
Orient
-
Integrated sequence
ACCCTGCGCTGAACATGGAGAACATCACATCAGGAT
Host Sequence
Chromosome
chr7
Cytoband
q35
Reference genome
GRCh37/hg19
Start
145810089/146112997 (Hg38)
End
145810124/146113032 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-10399/Upstream/2730197; hsa-mir-153-2/Downstream/1264985;
Nearest TSS
ENST00000635602/Upstream/431628; ENST00000637105/Downstream/2970;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1276837, chr7-CpG: 70/Downstream/3150
Nearby gene
TPK1(-1276943) ; CNTNAP2(+3363) ;
Nearest cancer related gene
CNTNAP2(TSG, +3363) ;
Upstream sequence
tagagccctcaccctctaatcatctcttaaatgttccacatcccaatactgttattctgtcaattaaatttcaacatgagttttgaagggggcactcaaa
Downstream sequence
TTTTTTTTAACCTATTGAAAATTCCTGAATTTTTCCAGTGCTTCATGCAATCACTTCAAAGTGTTAAGATTGAAATATTTTGACTCTTTTTTTTCACTTA
Target sequence
TTCTACTCCAAGGCACTCACCTAGACATATACCAA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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