Basic Information
VIS ID
TVIS10016519
Fusion event
HBV-chr8 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
1551
End
1586
Orient
+
Integrated sequence
CGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACT
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
109568002/108555773 (Hg38)
End
109568037/108555808 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-12123/Upstream/4071308; hsa-mir-10400/Downstream/4087685;
Nearest TSS
ENST00000518652/Upstream/81922; ENST00000521504/Downstream/25254;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/111739, chr8-CpG: 36/Downstream/231392
Upstream sequence
ATATCAAAATAGCAATGAAAAGTCTAACAGTAATAAATAATCTACTTAATTAATACAGTGGCACATTTCTCCATAATAGGTGAAAATTTGTGATTATAAA
Downstream sequence
TCCAGAATGTCTTCATTATTACCCAAAAGAATCAATAGTTGGAGACATTTCAGAAACCATCAAGTAAATTAAACCAGGCAGTTTGGGGAAGATTTTCTGG
Target sequence
TTCACACTTAAGTATGAATAAGCCTTCTTATTACT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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