Basic Information
VIS ID
TVIS10016527
Fusion event
HBV-chrX integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
638
End
673
Orient
+
Integrated sequence
CCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCT
Host Sequence
Chromosome
chrX
Cytoband
p22.31
Reference genome
GRCh37/hg19
Start
6629992/6711951 (Hg38)
End
6630027/6711986 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-3690-1/Upstream/327988; hsa-let-7f-2/Downstream/435874;
Nearest TSS
ENST00000429181/Upstream/176833; ENST00000217961/Downstream/9558;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/484086, chrX-CpG: 117/Downstream/435666
Nearby gene
VCX3A(-176833) ; PUDP(+336968) ;
Upstream sequence
CCACCTATGTCTAGAGAGTTATGAGAGTCAGAGTCTGTCACAAGACTTCCCATGCACTGGGTGGTAGAAAAACCCTGTGAAATGTACTTCATGTTCATGA
Downstream sequence
AGTCAGCATACTCGGGCTCTCTGGCTGGAGTTGACTCATCTCTAAACTGCTCTCCACATCCACAAAATAACTGCATGCCACCTATTGGTGCAGGGCTAGG
Target sequence
TACAGCATGTGCAGCATTCAATGTTTCTTTCCTGG
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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