Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016528
Fusion event
HBV-IL1RAPL1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1015
End
1050
Orient
+
Integrated sequence
TTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGC
Host Sequence
Chromosome
chrX
Cytoband
p21.2
Reference genome
Start
End
29514067/29495950 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-151a-5p ; hsa-mir-4307 ; hsa-mir-6768-5p ; hsa-mir-8485 ; hsa-mir-4446-5p ; hsa-mir-3679-3p ; hsa-mir-6840-5p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-574-5p ; hsa-mir-147a ; hsa-mir-7108-5p ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-6867-5p ; hsa-mir-644a ; hsa-mir-3911 ; hsa-mir-663b ; hsa-mir-5197-5p ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-4279 ; hsa-mir-100-3p ; hsa-mir-539-5p
Nearest miRNA
hsa-mir-23c/Upstream/1000252; hsa-let-7f-2/Downstream/78328;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1631860, chrX-CpG: 30/Downstream/751105
Upstream sequence
AAGTAGGAGGGCAGCCATTAACCAGGTTTCACCAGTGGGAAACTTTAGTAGCGAGGACATCAATGCCTTGCAATGGAGGCATCATGGCTCCTTCCTCCCA
Downstream sequence
CAATAAGTTCAGACATTTTTCTGCAGTCCCTAAGTAGGCAAATCTGAAGACCTCCTAGAACATCCAGCAAGCTTTGCAGTTATATCATACTGCAGCTATG
Target sequence
AACAACCTGGTCCTTAATTCCAGGCCTATTCTCTA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.