Basic Information
VIS ID
TVIS10016529
Fusion event
HBV-chrX integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Start
2965
End
3000
Orient
-
Integrated sequence
CACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGC
Host Sequence
Chromosome
chrX
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
30952184/30934067 (Hg38)
End
30952219/30934102 (Hg38)
Orient
+
Fragile sites / regions
FRAXC
Nearest miRNA
hsa-mir-23c/Upstream/1359709; hsa-let-7f-2/Downstream/1649554;
Nearest TSS
ENST00000429181/Upstream/44673; ENST00000439592/Downstream/40982;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/44456, chrX-CpG: 41/Downstream/137667
Upstream sequence
TGACAGCGCCTGGGCTGCATATTTCCCAAGGCAGGGGATACGGTGCTGGGCCGACACCCTCCCCGCAGCAGATTACCAGGGGAAACTAGTCACTGCTCCC
Downstream sequence
aaggcattttaatcatattgttgtgataattaaatgaattatcacatttaaaacccttagtttagtgtctgacacctaaaagctatatacatttaagcta
Target sequence
gaaattattccctcgtcagcaacgggaggataatg
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate