Basic Information
VIS ID
TVIS10016538
Fusion event
HBV-chr1 integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1782
End
1804
Orient
+
Integrated sequence
TCCAGTTGGCAGCACAGCCTAGC
Host Sequence
Chromosome
chr1
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
187813064/187843933 (Hg38)
End
187813211/187844080 (Hg38)
Orient
-
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/7405543; hsa-mir-1182/Downstream/4872248;
Nearest TSS
ENST00000473358/Upstream/202317; ENST00000569873/Downstream/374320;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1162984, chr1-CpG: 56/Downstream/4964422
Upstream sequence
TCCCTGGGATTCCCTTTCTCACTCTAGCGAGGAGGACTTGCACACGTTCTGGAACACTTCCCCAAATATGGTCCGAGGAAAGAAGTCCCTAGTGCCATCC
Downstream sequence
GGTCAATAAAAGACTTATAATTGTTTATAATTATTTTTCTTATTTCTCACCACTACTTAATATCAAGATTATTCCTTTTCTTTCACTTTGTCCTGCCTCT
Target sequence
ttGCAGTTGGTCACTGTGAATCCGTGGACCCTTGTGTATCTTCTTATTCCTGGCATAATGTCTCCAATGTATCCTGCACATACCCGACAGTGATAATTTCTTTAGAAATTAGCCTCTTAGTCATATAGTCAATATATGAAGTTACCA
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate