Basic Information
VIS ID
TVIS10016539
Fusion event
HBV-chr12 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1777
Orient
+
Integrated sequence
ACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCG| |CAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGAC
Host Sequence
Chromosome
chr12
Cytoband
p13.33
Reference genome
GRCh37/hg19
Start
1765582/1656416 (Hg38)
End
1765582/1656416 (Hg38)
Orient
+
Nearest miRNA
hsa-let-7i/Downstream/3899;
Nearest TSS
ENST00000382841/Upstream/11619; ENST00000540974/Downstream/32158;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/10339, chr12-CpG: 126/Downstream/5119
Nearby gene
WNT5B(-9204) ; MIR3649(+3898) ;
Upstream sequence
ACGCTGTCATCGCTGATGACACTGGAAGGGCGGCTGTAGCTCCGGGAGAGGCCCTCGGCAGGGACACCAGGCTCTGACAGGGATTCCAGTGTGGGCATTT
Downstream sequence
TTTTTTTGGTCTGGTTTTCTTGTATAGCATGTTTAATATTTGGCAATTAACATGGGTCCTCTTGTTCTATGACAGTAGTGAGAGAAGTTTCTTCTAATTT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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