Basic Information
VIS ID
TVIS10016549
Fusion event
HBV-MIR548W integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1260
Orient
+
Integrated sequence
AGGCTTCCCGATACAGAGCTGAGGCGGTATCTAGAAGATCTCGTACTGAAGGAAAGAAGTCAGAAGGCAAAAACGAGAGTAACTCCACAGTAGCTCCAAA| |TTCTTTATAAGGGTCGATGTCCATGCCCCAAAGCCACCCAAGGCACAGCTTGGAGGCTTGAACAGTAGGACATGAACAAGAGATGATTAGGCAGAGGTGA
Host Sequence
Chromosome
chr17
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
61052799/62975438 (Hg38)
End
61052799/62975438 (Hg38)
Orient
+
Location type
Intronic
Target gene
MIR548W
Nearest miRNA
hsa-mir-10226/Upstream/31126; hsa-mir-1250/Downstream/1525336;
Nearest TSS
ENST00000595228/Upstream/6889; ENST00000581424/Downstream/34118;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/8391, chr17-CpG: 19/Downstream/458854
Nearby gene
MARCH9(-167094) ; TANC2(+34098) ;
Upstream sequence
ACATATCCAAGGCTTACCTGCTCCTATTCACCTCTCAAATCAAATGCAAACACTGCCCTGGAGGCATGAGCAGGGGAGACGCTACCAGCCCTCAGAGCAC
Downstream sequence
TGGGCCTATGGAATGAAGACTTATTAAACCACATAAATAACCGTCCAACCACATACACCCATATTCTGCCTCAGGATCAGAGAATCAGCTTTTCCATTTT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate