Basic Information
VIS ID
TVIS10016555
Fusion event
HBV-chr3 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
2011
Orient
+
Integrated sequence
CAGTATGGATCGGCAGAGGAGCCGAAAAGGTTCCACGCATGCGCTGATGGCCCATGACCAAGCCCCAGCCAGTGGGGGTTGCGTCAGCAAACACTTGGCA| |CAGACCTGGCCGTTGCCGGGCAACGGGGTAAAGGTTCAGGTATTGTTTACACAGAAAGGCCTTGTAAGTTGGCGAGAAAGTGAAAGCCTGCTTAGATTGA
Host Sequence
Chromosome
chr3
Cytoband
q24
Reference genome
GRCh37/hg19
Start
144647963/144929121 (Hg38)
End
144647963/144929121 (Hg38)
Orient
+
Nearest miRNA
hsa-let-7g/Upstream/10491215; hsa-mir-1224/Downstream/6636755;
Nearest TSS
ENST00000440867/Upstream/955513; ENST00000482351/Downstream/1010791;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/955684, chr3-CpG: 97/Downstream/1231522
Nearby gene
DIPK2A(-936753) ; PLOD2(+1139264) ;
Upstream sequence
CCTAAAGTTCACTTTAGGACCTTTCTGTGTTATCACAGCTTATCTCCCTTTAGACTTCAAACACTTCAAAATATGACTTCACTACAAAGCTTTCCCTTGG
Downstream sequence
ACAATAAAGTTTCTGCAAAAAACAAAACAATCTGCTTATAGAAGGCAGCTCTGATATTTTTTGTCCTTAATTGTGTCATTATGGAACCGTAATGTATGTC
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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