VISDB Viral Integration Site DataBase

VIS ID

TVIS10016557

Fusion event

HBV-FGFR4 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Start

1541

Orient

-

Integrated sequence

CCAACTCCTCCCAGTCTTTAAACAAACAGTCTTTGAAGTATGCCTCAAGGTCGGTCGTTGACATTGCTGAGAGTCCAAGAGTCCTCTTATGTAAGACCTT| |GGGCAATATTTGGTGGGCGTTCACGGTGGTCTCCATGCGACGTGCAGAGGTGAAGCGAAGTGCACACGGTCCGGCAGATGAGAAGGCACAGACGGGGAGT

Chromosome

chr5

Cytoband

q35.2

Reference genome

Start

End

176520731/177093730 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-6796-5p ; hsa-mir-6742-5p ; hsa-mir-4447 ; hsa-mir-4472 ; hsa-mir-3151-5p ; hsa-mir-491-5p ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-6825-5p ; hsa-mir-6799-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6798-5p ; hsa-mir-3619-5p ; hsa-mir-761 ; hsa-mir-214-3p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-6838-5p ; hsa-mir-6510-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p

Nearest miRNA

hsa-mir-10397/Upstream/464230; hsa-mir-1229/Downstream/2704548;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/109, chr5-CpG: 35/Downstream/23169

Nearby gene

ZNF346(-26986) ; NSD1(+39348) ;

Nearest cancer related gene

FGFR4(OG, No orient, 0)

Upstream sequence

AGGACTCCCTTAGTCACTGTGAAAAATGAAACACCCTCACACATTGCTACTCACTCTAGGGAGGTGGGAGGAGATACCACACGCTAACGAGAACAACTGG

Downstream sequence

CCCGGCCTGACCAAGCCAGCACTGTGGCCGTCAAGATGCTCAAAGGTGAGTGTggcccggtgtggtggctcacacctgtaacgccagcactttaggaggc