VISDB Viral Integration Site DataBase

VIS ID

TVIS10016558

Fusion event

HBV-GTF2I integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Start

1676

Orient

-

Integrated sequence

TGCGACGTGCAGAGGTGAAGCGAAGTGCACACGGTCCGGCAGATGAGAAGGCACAGACGGGGAGTCCGCGTAAAGAGAGGTGCGCCCCGTGGTCGGTCGG| |AACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGC

Chromosome

chr7

Cytoband

q11.23

Reference genome

Start

End

74123529/74709198 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-21-5p ; hsa-mir-1229-3p ; hsa-mir-10a-3p ; hsa-mir-484 ; hsa-mir-23b-3p ; hsa-mir-99a-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-580-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-3121-3p

Nearest miRNA

hsa-mir-10525/Upstream/113172; hsa-mir-10399/Downstream/1205999;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/50446, chr7-CpG: 124/Downstream/78791

Nearby gene

GTF2IRD1(-106609) ; NCF1(+64779) ;

Upstream sequence

GAAAAAGACCGAAGGCATTTTTACAATTAGATCTTCTCATACTACCCCAGGGAAAACCATTAGCCCAGACTAGTTTAGCTGCTGACTAGAAATTTGTTCC

Downstream sequence

tacgtttctgcagctTACCAGACTTTTTTTTGGATTTACCtttttatttttatttatttatattttttgagacaaggtctcactctgtcgtccagactgg