Basic Information
VIS ID
TVIS10016560
Fusion event
HBV-CNTNAP3B integration
Validated
No
Detection method
RNA-Seq
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1777
End
1799
Orient
-
Integrated sequence
CAGGATCCAGTTGGCAGCACAGC
Host Sequence
Chromosome
chr9
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
40307323/41924055 (Hg38)
End
40307384/41924116 (Hg38)
Orient
+
Location type
Intronic
Target gene
CNTNAP3B
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-101-2/Upstream/690220; hsa-let-7a-1/Downstream/28885859;
Nearest TSS
ENST00000422679/Upstream/15374; ENST00000496386/Downstream/29091;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/24967, chr9-CpG: 42/Downstream/29004
Upstream sequence
AGAATCTTGTATTCAAGAGGCAGTCTCGTATTTGAAAGGCACTCACCTGTTCTGGGCACTGGGAGATGAGTGGGTGGGGACAGAGAGGGGGCAGCCGAGG
Downstream sequence
TCATACCTTCATTTCCCTGCTTTCCACGGAGAACTCACTGCTGACGTGTGCTTCTTTTTTAAGACCACAGTTTCCTCTGGGGTGTTTATGGAGAACCTGG
Target sequence
GTCGTTTTCTCTATTGTAAACAGAGTCATTTTGGAATTCAGCTTCCTTCAACACTGAGACT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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