Basic Information
VIS ID
TVIS10016561
Fusion event
HBV-chrX integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1629
Orient
-
Integrated sequence
ATGTAAGACCTTGGGCAATATTTGGTGGGCGTTCACGGTGGTCTCCATGCGACGTGCAGAGGTGAAGCGAAGTGCACACGGTCCGGCAGATGAGAAGGCA| |CAGACGGGGAGTCCGCGTAAAGAGAGGTGCGCCCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTC
Host Sequence
Chromosome
chrX
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
54401135/54374702 (Hg38)
End
54401135/54374702 (Hg38)
Orient
+
Nearest miRNA
hsa-let-7f-2/Upstream/817428; hsa-mir-105-1/Downstream/1076793;
Nearest TSS
ENST00000429181/Upstream/16060; ENST00000375151/Downstream/65699;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/15658, chrX-CpG: 129/Downstream/120310
Nearby gene
WNK3(-16697) ; TSR2(+65717) ;
Upstream sequence
AAACATATTTTTTCAACAAAAATCAGTGTTATCAAAAACAAGTAAGTTAGGGGCTGTGTGTGTTCTTTTACAATTTCATTTTCACATTCCCTGTAGGTAT
Downstream sequence
CAGCAGATCCATCCATGTCACGTACCTGCTTAAAGCTCTTCAATGGTcttccagccatgatagaataataggggacgtatttactctctgccttaaacaa
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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