DENND5A _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016564
Fusion event
HBV-DENND5A integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
552
Orient
+
Integrated sequence
GAAGTAATGATTAACTAGATGTTCTGGATAATAAGGTTTAATACCCTTATCCAATGGTAAATATTTGGTAACCTTTGGATAAAACCTGGCAGGCATAATC| |AATTGCAATCTTCTTTTCTCATTAACTGTGAGTGGGCCTACAAACTGTTCACATTTTTTGATAATGTCTTGGTGTAAATGTATATTAGGAAAAGATGGTG
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
9207420/9185873 (Hg38)
End
9207420/9185873 (Hg38)
Orient
+
Location type
Intronic
Target gene
DENND5A
miRNAs that regulate target gene
hsa-mir-30d-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-210/Upstream/95494; hsa-let-7a-2/Downstream/1322397;
Nearest TSS
ENST00000527297/Upstream/6924; ENST00000630083/Downstream/20845;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/94058, chr11-CpG: 113/Downstream/78853
Nearby gene
KRT8P41(-89683) ; TMEM41B(+94780) ;
Upstream sequence
GTTTATTTGTTAGATCCTATGTATTTGGCTATTCTCATCTCTTGTACAAGTGAGGTTCACTAGTCCGAACCTCTTTACTTTCCATTTTGGCGTCTTTTGG
Downstream sequence
gcctatcatctttgtcgtattgcatttgttagaagttaggtcacaagtcccacccacactcgaggggcagggactacacaggctgtggatacaaggagat
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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