Basic Information
VIS ID
TVIS10016566
Fusion event
HBV-WT1-AS integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
3193
Orient
-
Integrated sequence
AGGGTTTACTGTTCCTGAACTGGAGCCACCAGCAGGGAAATACAGGCCTCTCACTCTGGGATCTTGCAGAGTTTGGTGGAAGGTTGTGG| |
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
32458297/32436751 (Hg38)
End
32458297/32436751 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11E
Target gene
WT1-AS
Nearest miRNA
hsa-mir-210/Upstream/3959203; hsa-let-7a-2/Downstream/2505086;
Nearest TSS
ENST00000527297/Upstream/1121; ENST00000532054/Downstream/147047;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/986, chr11-CpG: 33/Downstream/1125
Nearby gene
WT1(-1216) ; EIF3M(+147093) ;
Upstream sequence
TTACATACCTGTTCTATAACTTCTTTGGAAACTGTATGTATGTTAGGGTGTGACTGGATTCTGAAGCCAGAATTTCACAGTACACATTTTTCCACATCTG
Downstream sequence
agagtcttgctctggcacccaggcttgaatgcagtggcacgatctcagctcactgcagtctccacctcctgggttcaagcgattctcctgcctcagcctc
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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