Basic Information
VIS ID
TVIS10016568
Fusion event
HBV-ASS1P14 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1852
Orient
-
Integrated sequence
GGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATC| |AGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGAGGAGCCGAAAAGGTTCCACGCATG
Host Sequence
Chromosome
chr12
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
33139135/32986201 (Hg38)
End
33139135/32986201 (Hg38)
Orient
-
Location type
Intronic
Target gene
ASS1P14
Nearest miRNA
hsa-mir-1244-3/Upstream/7112122; hsa-let-7i/Downstream/9337499;
Nearest TSS
ENST00000382841/Upstream/89361; ENST00000549660/Downstream/2562;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/89092, chr12-CpG: 128/Downstream/452627
Nearby gene
PKP2(-89355) ; SYT10(+389212) ;
Upstream sequence
TTGTAACAATTTGTAGATTCTTATGCTGTTGCTCCTATGCTATTACTTAAGCTATATTATCAATGCATTTTAAATGACATTTTAATAAATATTTAGGTAC
Downstream sequence
TTGGGGATGTAACTATCACCAAGGCGATATGGAATTTCGTTGGAAGCTTTCTGAGCTTCTGCAGAAACATATTTAATTTTAAGATACAAGAAAACAAAAC
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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