THAP8 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016579
Fusion event
HBV-THAP8 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
809
Orient
+
Integrated sequence
CCACCTTATGAGTCCAAGGAATACTAACATTGAGATTCCCGAGATTGAGATCTTCTGCGACGCGGCGATTGAGACCTTCGTCTGCGAGGCGAGGGAGTTC| |TTCTTCTAGGGGACCTGCCTCGTCGTCTAACAACAGTAGTCTCCGGAAGTGTTGATAGGATAGGGGCATTTGGTGGTCTATAAGCTGGAGGAGTGCGAAT
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
36538198/36047296 (Hg38)
End
36538198/36047296 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
THAP8
miRNAs that regulate target gene
hsa-mir-3149 ; hsa-mir-6788-3p ; hsa-mir-411-5p ; hsa-mir-4775 ; hsa-mir-193b-5p ; hsa-mir-92b-5p ; hsa-mir-4735-5p ; hsa-mir-7845-5p ; hsa-mir-590-3p
Nearest miRNA
hsa-mir-10395/Upstream/701669; hsa-let-7e/Downstream/3362327;
Nearest TSS
ENST00000633603/Upstream/13953; ENST00000608676/Downstream/7081;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/14311, chr19-CpG: 111/Downstream/6803
Nearby gene
CLIP3(-14401) ; WDR62(+7584) ;
Upstream sequence
acatgtaagtgagaaaatgtggtatttggtttccttttcctgcattagtttgctaaagataatggcctccaacttcttccatgtctaaaaaggacatgat
Downstream sequence
ttcccagcctcttttccagttggggtgaccaatgatgaaaaggtgccattgaacggggtttctgggaaggccttataaagggagatgattcagtttagac
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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