Basic Information
VIS ID
TVIS10016580
Fusion event
HBV-LOC107985340 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
633
Orient
-
Integrated sequence
AAACCTGGCAGGCATAATCAATTGCAATCTTCTTTTCTCATTAACTGTGAGTGGGCCTACAAACTGTTCACATTTTTTGATAATGTCTTGGTGTAAATGT| |ATATTAGGAAAAGATGGTGTTTTCCAATGAGGATTAAAGACAGGTACAGTAGAAGAATAAAGCCCAGTAAAGTTCCCCACCTTATGAGTCCAAGGAATAC
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
49767939/49264682 (Hg38)
End
49767939/49264682 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
LOC107985340
Nearest miRNA
hsa-mir-10395/Upstream/254710; hsa-let-7e/Downstream/44115;
Nearest TSS
ENST00000633603/Upstream/53948; ENST00000597602/Downstream/44270;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/53820, chr19-CpG: 32/Downstream/73248
Nearby gene
TRPM4(-52841) ; SLC6A16(+24952) ;
Upstream sequence
GCCTGGGGGGATTTTGATCCCATTCTCAGGCCAACTCTGAAATTCCTTCCTGACAGATGGACTTTTCCTTGTACATCATTAGCCATGTAGGCATTATCAT
Downstream sequence
aaaaaagatccagttactgatgcccccaaaacacgaaGCTCAAAAGCTTTTCAGatttaattaataattttaatggttaataaagtatattctttttaaa
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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