Basic Information
VIS ID
TVIS10016581
Fusion event
HBV-IGK integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
2261
Orient
-
Integrated sequence
GGCAGCAAAACCCAAAAGACCCACAATTCGTTGACATACTTTCCAATCAATAGGCCTGTTAATAGGAAGTTTTCTAAAACATTCTTTGATTTTTTGTATG| |ATGTGTTCTTGTGGCAAGGACCCATAACATCCAATGACATAACCCATAAAATTTAGAGAGTAACCCCATCTCTTTGTTTTGTTAGGGTTTAAATGTATAC
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
89868269/89829459 (Hg38)
End
89868269/89829459 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
IGK
Nearest miRNA
hsa-mir-1285-2/Upstream/1017005; hsa-mir-10b/Downstream/6968819;
Nearest TSS
ENST00000437798/Upstream/499030; ENST00000429992/Downstream/22332;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/61358, chr2-CpG: 65/Downstream/408589
Nearby gene
ANKRD36BP2(-762160) ; LSP1P4(+1956439) ;
Upstream sequence
CAGTCTCTGCAAGGACTGGCAGCAGACGGCGCTCACCCTGGGAGACCGAGTCCAGACACCTGTTCCCTGGCACAGCAGAAGCCCTCCACCCAGGCCCTGG
Downstream sequence
attccattccattccattccattccattccattccattccattccattccactcaggttgattctattccattccatgccattccattccattctattcc
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate