LRP1B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016582
Fusion event
HBV-LRP1B integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1910
Orient
-
Integrated sequence
TGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCC| |GCAGTATGGATCGGCAGAGGAGCCGAAAAGGTTCCACGCATGCGCTGATGGCCCATGACCAAGCCCCAGCCAGTGGGGGTTGCGTCAGCAAACACTTGGC
Host Sequence
Chromosome
chr2
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
141269654/140512085 (Hg38)
End
141269654/140512085 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LRP1B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-200c-3p ; hsa-mir-106b-3p ; hsa-mir-5692a
Nearest miRNA
hsa-mir-128-1/Upstream/4846607; hsa-mir-10b/Downstream/74541;
Nearest TSS
ENST00000437798/Upstream/154017; ENST00000410015/Downstream/1298316;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1731005, chr2-CpG: 58/Downstream/1618070
Nearby gene
YY1P2(-1612910) ; KYNU(+2365540) ;
Nearest cancer related gene
LRP1B(TSG, No orient, 0)
Upstream sequence
AAGTAAAATGAACTTCTGAGCCAAATTAATTACTGTCTGAAGTGTTGACATGCTTGAAACTTGACATGAATATACAACTCGATCAGACTTCATTTTGGCT
Downstream sequence
AATTTGTTCTCAAGGCAGTCATAATAGAAAGAGCCCCGATTTGGCAGTGGAGAAATctaattctgtatgaccttgatgaagactagtgtctgaattaccc
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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