VISDB Viral Integration Site DataBase

VIS ID

TVIS10016583

Fusion event

HBV-BMPR2 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Start

1340

Orient

-

Integrated sequence

AACTCCACAGTAGCTCCAAATTCTTTATAAGGGTCGATGTCCATGCCCCAAAGCCACCCAAGGCACAGCTTGGAGGCTTGAACAGTAGGACATGAACAAG| |AGATGATTAGGCAGAGGTGAAAAAGTTGCATGGTGCTGGTGCGCAGACCAATTTATGCCTACAGCCTCCTAGTACAAAGACCTTTAACCTAATCTCCTCC

Chromosome

chr2

Cytoband

q33.1

Reference genome

Start

End

203271359/202406636 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-20a-5p ; hsa-mir-21-5p ; hsa-mir-129-5p ; hsa-mir-92a-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-17-5p ; hsa-mir-100-5p ; hsa-mir-302c-3p ; hsa-mir-130a-3p ; hsa-mir-181c-5p ; hsa-mir-128-3p ; hsa-mir-215-5p ; hsa-mir-7-5p ; hsa-mir-192-5p ; hsa-mir-93-5p ; hsa-mir-26b-5p ; hsa-mir-93-3p ; hsa-mir-135a-5p ; hsa-mir-181a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-32-5p ; hsa-mir-181b-5p ; hsa-mir-181d-5p ; hsa-mir-92b-3p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-548c-3p ; hsa-mir-135b-5p ; hsa-mir-4716-5p ; hsa-mir-4772-3p ; hsa-mir-3615 ; hsa-mir-1304-3p ; hsa-mir-125b-1-3p ; hsa-mir-6890-3p ; hsa-mir-6800-3p ; hsa-mir-6787-3p ; hsa-mir-6736-3p ; hsa-mir-4693-5p ; hsa-mir-103a-2-5p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-550b-3p ; hsa-mir-892c-3p ; hsa-mir-4676-3p ; hsa-mir-452-5p ; hsa-mir-100-3p ; hsa-mir-490-5p ; hsa-mir-153-3p

Nearest miRNA

hsa-mir-10b/Upstream/13273525; hsa-mir-1244-1/Downstream/4376598;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/28941, chr2-CpG: 115/Downstream/228043

Nearby gene

NOP58(-102975) ; FAM117B(+228541) ;

Nearest cancer related gene

BMPR2(TSG, No orient, 0)

Upstream sequence

TATTAATTCCTACTATTTCTGCCAAAGTCATCCTACTATGTTGTTTTAAAGTAAAGAAACCTACTTCTAGATGGTCCCATTTGTGGGATGGAATCGTGGG

Downstream sequence

GGAAACCATACAGAATTGAGCATCAATGAATAAATAAACCTCTGCCAGAGATTGGCAGGCTTTTTGGATCATGGTGTCATTCCAAGTTAGGGTTAGGCAC