Basic Information
VIS ID
TVIS10016590
Fusion event
HBV-chr5 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1871
Orient
-
Integrated sequence
CCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCT| |CCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGAGGAGCCGAAAAGGTTCCACGCATGCGCTGATGGCCCATGACCA
Host Sequence
Chromosome
chr5
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
67508314/68212486 (Hg38)
End
67508314/68212486 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-10397/Upstream/8508783; hsa-mir-103a-1/Downstream/3956981;
Nearest TSS
ENST00000502646/Upstream/22610; ENST00000517643/Downstream/3234;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1048719, chr5-CpG: 159/Downstream/2558
Nearby gene
CD180(-1015697) ; PIK3R1(+14147) ;
Nearest cancer related gene
PIK3R1(OG, +14147) ;
Upstream sequence
TAAAAATCACAGTtctgggtctgaggctcctcatctggcagaaagtgttcataacctcaggaggtggttatgaagattaaaagaagcaaaaagttgaatg
Downstream sequence
aaaaaaggttgaattcattgccagcattcaataattggaaaatagtccataaaaatctgtattttcagcttctctaggaaaattggaaaatttgggctca
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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