Basic Information
VIS ID
TVIS10016591
Fusion event
HBV-chr5 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1422
Orient
-
Integrated sequence
CAGTAGGACATGAACAAGAGATGATTAGGCAGAGGTGAAAAAGTTGCATGGTGCTGGTGCGCAGACCAATTTATGCCTACAGCCTCCTAGTACAAAGACC| |TTTAACCTAATCTCCTCCCCCAACTCCTCCCAGTCTTTAAACAAACAGTCTTTGAAGTATGCCTCAAGGTCGGTCGTTGACATTGCTGAGAGTCCAAGAG
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
80539780/81243961 (Hg38)
End
80539780/81243961 (Hg38)
Orient
-
Location type
Intronic
Target gene
CKMT2 ; CKMT2-AS1
Nearest miRNA
hsa-mir-10397/Upstream/8365298; hsa-mir-103a-1/Downstream/1596194;
Nearest TSS
ENST00000502646/Upstream/10622; ENST00000505135/Downstream/8772;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/282774, chr5-CpG: 39/Downstream/57540
Nearby gene
RASGRF2(-17827) ; ZCCHC9(+57621) ;
Upstream sequence
tggtcccaccaaatctcatgttcttacatctcaaaaccaatcatgccttcccaacagtcctccaaagtcttaactcatttcagtattaacctaaaagtcc
Downstream sequence
ggattacaggcataagccaccatgcccagtcCCTAATATGATCTTATTTAGTTGACATTTGCCTCTTTCCCCAAAAATAGATCAAAGGAAATGTTTCCCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
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