Basic Information
VIS ID
TVIS10016598
Fusion event
HBV-chr8 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22267523
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1824
Orient
+
Integrated sequence
GGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTAT| |ATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGG
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
108520648/107508420 (Hg38)
End
108520648/107508420 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-12123/Upstream/3023955; hsa-mir-10400/Downstream/5135073;
Nearest TSS
ENST00000518652/Upstream/10365; ENST00000520037/Downstream/481135;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/850057, chr8-CpG: 92/Downstream/574207
Nearby gene
ANGPT1(-10394) ; RSPO2(+390895) ;
Upstream sequence
atatttcgtgtactttgatattttatgtacagtatataatatgtaattggtgtaatttgatattttatgttcagtatataatatgtatttggtgtacttt
Downstream sequence
AAGCCTTTAAAGAATAAAATATTTGTGTATTGATCACACGTGAGCACAATGTTGACTTTCATGTAATAGTTAACAATTGCTGTTATGACATTTTGTCTCT
Reference
Jiang, S., et al. Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis. PLoS One ,2012, 7(9): e40363.
Curate