Basic Information
VIS ID
TVIS10016925
Fusion event
HBV-LOC105369617 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1851
End
1941
Integrated sequence
TCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGG
Host Sequence
Chromosome
chr12
Cytoband
p13.32
Reference genome
GRCh37/hg19
Start
5402781/5293615 (Hg38)
End
5402881/5293715 (Hg38)
Location type
Intronic
Target gene
LOC105369617
Nearest miRNA
hsa-mir-3649/Upstream/3633235; hsa-let-7i/Downstream/1669984;
Nearest TSS
ENST00000382841/Upstream/3135; ENST00000544842/Downstream/22246;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/150211, chr12-CpG: 56/Downstream/137014
Upstream sequence
CCTGGGCACTTCTCTCACCAGGCCCTGCATCGCCTGCAAACAAGTGGAAATTGCCCACCGGGAGGGGGCCAAGTATGTGTCCCATGGCGTCACGGGAAAG
Downstream sequence
TTTCTGTTCTTGTTTTCAAACTATATGGACTCAGCTAGCTTACAAGATATGGAAGACAGCTAGAAGGAGGCAACCCAGCCCAGGAAGGCAGGTTGGATTC
Target sequence
CTGCCCCAGGAAGACTGTGGTACAGGTGCCTGGGGAGCAGGCTGCTAGGAGAGGTTTGGTAGGAGTGCCCTGGGTTAAGGTGAAGAATAGCATCCTCTTC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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