Basic Information
VIS ID
TVIS10016926
Fusion event
HBV-LOC105369617 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1713
End
1803
Integrated sequence
AGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGC
Host Sequence
Chromosome
chr12
Cytoband
p13.32
Reference genome
GRCh37/hg19
Start
5403676/5294510 (Hg38)
End
5403763/5294597 (Hg38)
Location type
Intronic
Target gene
LOC105369617
Nearest miRNA
hsa-mir-3649/Upstream/3634130; hsa-let-7i/Downstream/1669102;
Nearest TSS
ENST00000382841/Upstream/4030; ENST00000544842/Downstream/21364;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/151106, chr12-CpG: 56/Downstream/136132
Upstream sequence
agagttgaacattccccttgatagagcagttttgaaacactctttctgtagaatctgcatgtggatatttggacctctttgaggccttcgttggaaatgg
Downstream sequence
ttggagtcctagactgccacttagtagctatgtggctctgtagaagtcacttcccctccctgggccaccactttctcatctgtaaattagagctggactg
Target sequence
AAGGACTGGGCTGTGAGCCACCAGTAGCCAATACTCCACCCCTCACCTCAGTTCTGAagggggcatctgggcttcaggaaatcgggg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate