Fusion event
HBV-SLMAP integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
CTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGAC
End
57896556/57910829 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7g/Upstream/2058165; hsa-mir-12124/Downstream/2706976;
Upstream sequence
acaaggtctcatgtgttgtctaggctggtcttgaactcctgggctcaagtaatactctcaccttggcttcccaaagtgctgggattactggcatgagcca
Downstream sequence
AATCACTATTCAGAAGAGAAGGGAGAGTCATTGTACGAGGCCCAAGATACTTGCCCAAAAATATCGCAGAGAAAAACTAGTCTTTGGGGTCCTATTTTTT
Target sequence
AAGAAGGAGCCAATGTTGTTTTAAAATTTTAGCTTGAGAGATAGGTGGGGAAGAAATTAAATAGACAAGT
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.