Basic Information
VIS ID
TVIS10016931
Fusion event
HBV-LINC02329 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
711
End
801
Integrated sequence
CTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGT
Host Sequence
Chromosome
chr14
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
85848849/85382505 (Hg38)
End
85848944/85382600 (Hg38)
Location type
Intron
Target gene
LINC02329
Nearest miRNA
hsa-mir-1260a/Upstream/8116215; hsa-mir-1185-1/Downstream/8565626;
Nearest TSS
ENST00000550708/Upstream/143031; ENST00000554753/Downstream/4675;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/3848415, chr14-CpG: 45/Downstream/147550
Upstream sequence
TAGAAGATTTGCACTTTTACGAGGAAATTGTGCTGTGATAAACAGCATCAAACACCTTATTATATTTTAAATATGTGTGTAAATTATGTCTGTGAGACTC
Downstream sequence
TAAGAGTGGATGCATTATTTCTAACTTACTTGAATTTTCAGAAGACTGAATGAGATAACATTAATACCTCTAAAAAAGTAAACACTTAATAAATGTTAGC
Target sequence
GTACAATACAGTAAAACAGTAGAACGGAGAATGTGGTGGGAAGGAATGCATATTTAAATATGCATATATTTAACTCATATGCATATTTGAATAAG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate