LGI4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016932
Fusion event
HBV-LGI4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1646
End
1719
Integrated sequence
AGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGT
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
35628238/35137334 (Hg38)
End
35628306/35137402 (Hg38)
Location type
Promoter
Fragile sites / regions
FRA19A
Target gene
LGI4
Nearest miRNA
hsa-mir-10395/Upstream/14570; hsa-let-7e/Downstream/208111;
Nearest TSS
ENST00000633603/Upstream/2134; ENST00000587056/Downstream/1406;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/10598, chr19-CpG: 32/Downstream/3913
Upstream sequence
gggaggctgaggtaggaggatccctgaaacctggaaagttcaggctgcagtgagctgtaattgcaccactacgctccagcaggagtgacagagcgagacc
Downstream sequence
GTGGCCAACCATGTGCCTGTTTGCTCAAGCATAGGGTGTGAACCAGTGTGTGTGTTTCTGCTTTTGTGGGTATGTGTGAGAGCGGCGGGTTGTCCTTGAT
Target sequence
GTTAAATACATATCTGTGGTTTTGGAATGTGTGAACATGCAAGTGTGTCAGCCTGCGCATCTGTCACC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate