LGI4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10016933
Fusion event
HBV-LGI4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
50
End
139
Integrated sequence
GTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGG
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
35628104/35137200 (Hg38)
End
35628190/35137286 (Hg38)
Location type
Promoter
Fragile sites / regions
FRA19A
Target gene
LGI4
Nearest miRNA
hsa-mir-10395/Upstream/14436; hsa-let-7e/Downstream/208227;
Nearest TSS
ENST00000633603/Upstream/2000; ENST00000587056/Downstream/1522;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/10464, chr19-CpG: 32/Downstream/4029
Upstream sequence
TGGGgtggcatatactgctagaagtcctttttttctttcttactaatgtaactcaaaatttcttcaggctgattaaatgcccagtttttaaagaccacaa
Downstream sequence
GCCAGGTGTGTTGTCCCCGACAAGAGCTCAGGGGAAGGAAAGTGTGGGGTTAAATACATATCTGTGGTTTTGGAATGTGTGAACATGCAAGTGTGTCAGC
Target sequence
agttcacacaaccaggagtgcagtgcctgggccattccaggtttccctgtcaccaggacctgtAAACCTGGCCTGCCCATGGGGAC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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