Basic Information
VIS ID
TVIS10016934
Fusion event
HBV-LOC105377567 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2910
End
3000
Integrated sequence
CAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGC
Host Sequence
Chromosome
chr4
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
181354871/180433718 (Hg38)
End
181354967/180433814 (Hg38)
Location type
Intronic
Target gene
LOC105377567
Nearest miRNA
hsa-mir-12113/Upstream/6009854; hsa-mir-1305/Downstream/1735479;
Nearest TSS
ENST00000502981/Upstream/968413; ENST00000512480/Downstream/325224;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/374252, chr4-CpG: 20/Downstream/1707311
Upstream sequence
AGGAGGAGGGCTGTTTACCAGCAGTGGCAACATTGGAATGGCCCTGCCTAACGACATGTATGACTTGCATGACCTTTCCAAAGCTGAACTGGCCGCACCT
Downstream sequence
AGGTATTCTTCCTTTAACCACCACAATTACCTCATGCTATACTAGTCCTAAGAACTCTAATGTTCAGTGGATAAATAAGCTATATAGAAAGTAAGTGGGG
Target sequence
AGATTGGAAGAATAAGTAATTTTAACGTATCATCAGTTTATGACAATTTCTAAAATGTAATCAGTTACTTTCCAGGTTCTGGGCAAAGTTCTTTAC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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