Basic Information
VIS ID
TVIS10016935
Fusion event
HBV-MIR4456 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1678
End
1768
Integrated sequence
GCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCT
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
538388/538273 (Hg38)
End
538479/538364 (Hg38)
Location type
Promoter
Target gene
MIR4456
Nearest miRNA
hsa-mir-10397/Downstream/524532;
Nearest TSS
ENST00000502646/Upstream/13568; ENST00000512038/Downstream/73846;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/866, chr5-CpG: 35/Downstream/16344
Upstream sequence
aatgcttgaatcccctagggatctgatgcaaatgcaaattcaggccaggtgcggtggctcacgcctgtaatcccagccctttgggaggctgaggcgggcg
Downstream sequence
CTTCACAGGGAAGCCCCCAGATTCTCCTCCAAAGCCTGGAGTCACCGACGGCAGAAGCAGGGCTGAAAGGGCACCTGGATGGCCAGGTGGGCAGGCGGCT
Target sequence
TGACCCACGGCCCCGGGTCGCAGGCGTTCCGCTAGTGGCCAGCGCATCATCAGCCACGTTCTTGGCGTGCCGCTCCTGCGGGTCTCACCCC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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